Abstract

Overview

Alzheimer's disease (AD) represents a major public health issue and poses substantial economic challenges. Recent studies suggest that radiofrequency electromagnetic fields (RF-EMFs) might alleviate symptoms associated with AD.

Objective

The study aims to explore if RF-EMFs emitted by cell-phones could impact AD risk.

Material and Methods

• Examination of 33 relevant studies linking cell phone use with AD from international databases.
• Discussion on RF-EMF effects on amyloid β (Aβ), oxidative stress, and more.
• Analysis of exposure parameters like exposure type, duration, and specific absorption rate (SAR).

Findings

• Reduction in progressive AD factors such as amyloid β and others, with some factors showing increase like GFAP and MAPKs related to brain activity.
• No change was noted in tau protein levels.

Conclusion

Low-level RF-EMF exposure can potentially reduce AD risk by influencing various molecular and cellular pathways. However, it's noted that RF-EMFs have a dual role, which could either reduce incidence or accelerate AD progression depending on many exposure parameters.

The need for further research to define optimal exposure settings and translate animal model data to human effects is emphasized.