900 MHZ electromagnetic field exposure relieved Alzheimer's Disease-like symptoms on APP/PS1 mice

Abstract

Overview

Emerging evidence highlights that electromagnetic fields (EMFs) may exert various biological effects on the central nervous system, particularly concerning their role in neurodegenerative diseases like Alzheimer’s Disease (AD).

Methods

• Long-term exposure to 900 MHz microwave radiation over 270 days, employing Specific Absorption Rates (SAR) of 0.25–1.055 W/kg for 2 hours/day, was tested on both genetically modified and wild-type mice.
• Cognitive assessments were carried out using Morris water maze, Y maze, and new object recognition tests.
• Biochemical analyses via Congo red staining, immunohistochemistry, and ELISA were conducted to investigate Aβ plaques and Aβ40 and Aβ42 content in the brain.
• Proteomics assisted in identifying differentially expressed proteins in the hippocampus of exposed and unexposed AD mice.

Findings

The study found that long-term exposure to microwave radiation improved spatial and working memory in AD mice compared to sham-exposed mice. Importantly, the radiation did not induce Aβ plaque formation in wild-type mice yet inhibited Aβ accumulation in the cerebral cortex and hippocampus of APP/PS1 mice, an effect observed mainly in the later stages of the disease. Possible mechanisms may include downregulation of apolipoprotein and SNCA expression and rebalancing excitatory/inhibitory neurotransmitters in the hippocampus.

Conclusion

This research implies that prolonged 900 MHz microwave exposure might retard AD development and offer beneficial effects against Alzheimer’s Disease, proposing it as a potential non-invasive therapy for AD.