The dose-dependent effect of 1.5-GHz microwave exposure on spatial memory and the NMDAR pathway in Wistar rats

Authors: Wang H, Song L, Zhao L, Wang H, Xu X, Dong J, Zhang J, Yao B, Zhao X, Peng R

Year: 2022

Category: Environmental Science and Pollution Research

Journal: Environ Sci Pollut Res Int

DOI: 10.1007/s11356-022-24850-4

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792922/

Abstract

Overview

This study investigates the impacts of 1.5-GHz microwave exposure on cognitive functions, particularly spatial memory, in male Wistar rats. With the growing concerns regarding microwave radiation's potential health risks, this research provides crucial insight into its effects on the brain, a vulnerable target organ.

Findings

The experiment involved 140 rats divided into groups with varying exposure levels: no exposure, low, medium, and high power density. The researchers monitored changes in brain function and structure, focusing on:

  • Learning and memory abilities
  • Hippocampal structure changes
  • NMDAR signalling pathway molecules

Significant findings revealed spatial memory impairment and structural brain changes at higher exposure levels.

Conclusion

Exposure to 1.5-GHz microwaves at varying power densities from 5 to 50 mW/cm² demonstrates a dose-dependent effect on spatial memory and neuronal structural integrity, with potential long-term implications for cognitive health.

microwave radiation spatial memory NMDAR pathway Wistar rats cognitive functions EEG activity dose-dependent effect
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