Effect of Terahertz Electromagnetic Field on the Permeability of Potassium Channel Kv1.2

Authors: Ding W, Zhao X, Wang H, Wang Y, Liu Y, Gong L, Lin S, Liu C, Li Y

Year: 2023

Category: Molecular Biology

Journal: Int J Mol Sci

DOI: 10.3390/ijms241210271

URL: https://www.mdpi.com/1422-0067/24/12/10271

Abstract

Overview

In the study, the team explored how terahertz electromagnetic fields at frequencies of 4 THz, 10 THz, 15 THz, and 20 THz impact the Kv1.2 voltage-gated potassium ion channel on nerve cell membranes. The research utilized a "Constant Electric Field-Ion Imbalance" molecular dynamics model.

Findings

  • Terahertz electromagnetic fields do not resonate strongly with the amino acid sequence in the ion channel but destabilize the electrostatic and hydrogen bonds within the channel structure.
  • At 15 THz, the stability of necessary chemical bonds decreased, altering ion states and the permeation mode's probability, specifically decreasing the "soft knock on" mode by 46.9% and increasing ion flux by 67.7%.

Conclusion

This research supports the hypothesis that terahertz electromagnetic fields can alter ion channel permeability, which can be pivotal in understanding and potentially managing conditions linked to irregular ion channel function.

terahertz electromagnetic fields ion channels molecular dynamics Kv1.2 membrane permeability ion channel diseases
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