Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels

Authors: Hernández-Morales M, Shang T, Chen J, Han V, Liu C

Year: 2020 Mar 10

Category: Biochemistry

Journal: Cell Rep

DOI: 10.1016/j.celrep.2020.02.070

URL: https://www.ncbi.nlm.nih.gov/pubmed/32160534

Abstract

Overview

This study explores the effects of radiofrequency (RF) waves on lipid oxidation and iron dynamics within cellular ferritins, illuminating a potential magnetogenetic application for activating specific ion channels.

Findings

  • RF waves aid in the activation of transient receptor potential channels (TRPV1 and TRPV4) tagged to cellular ferritins. The heat generated by RF fields is significantly weaker than what is typically required for such activation.
  • The activation process utilizes the FeRIC (Ferritin iron Redistribution to Ion Channels) system, where ferritin disturbance and associated iron mediate biochemical pathways.
  • In cells with TRPVFeRIC channels, RF exposure increases the labile iron pool through a ferritin-dependent mechanism.
  • This influx of free iron contributes to various chemical reactions, resulting in reactive oxygen species and lipid oxidations that activate TRPVFeRIC channels.

Conclusion

The identified mechanism suggests a broader applicability of RF-induced activation across various lipid-sensitive TRP channels, offering directions for future research in magnetogenetic technology designs.

magnetogenetics radiofrequency waves TRP channels ferritin lipid oxidation iron biochemical pathways
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