Abstract

Overview

The study aimed to explore the impacts of low-level 915 MHz GSM-modulated RF radiation on microtubular structures and normal cell proliferation.

Methodology

• Cells and Exposure: V79 cells were exposed to GSM-modulated RF radiation in a Gigahertz Transversal Electromagnetic Mode cell for durations of 1, 2, and 3 hours.
• Electromagnetic Field Generation: This field was generated using a signal generator with power and chip modulator, setting electric field strengths of 10, 20, and 30 V/m. The specific absorption rates (SAR) averaged 0.23, 0.8, and 1.6 W/kg respectively.

Findings

• Microtubular Integrity: The structure of microtubule proteins was evaluated via indirect immunocytochemistry.
• Impact on Cell Growth: Significant alterations in microtubule structure were observed following three hours of exposure, regardless of field strength. Additionally, on the third post-exposure day, a significant reduction in cell growth was noted particularly after three-hour exposure and two-hour exposure at higher field strengths of 20 and 30 V/m.

Conclusion

The study concluded that 915 MHz GSM-modulated RF radiation negatively impacts microtubular proteins in a time-dependent manner, thereby affecting cell proliferation. Further studies are planned to investigate these effects throughout different stages of the cell cycle and on the mitotic spindle.