Abstract

Overview

In this study, we meticulously observed the impacts of weak static magnetic fields (SMFs) of varied intensities on HT-1080 human fibrosarcoma cells over a period of four days.

Experimental Setup

• Magnetic Field Exposure: Cells were exposed to SMFs ranging from 0.5 to 600 µT for treated units, with control exposures maintained at 45 µT.
• Data Collection: Measurements included cell growth rates via cell counts and assessments of various cellular components like membrane potentials and oxidative stress indicators using fluorescent dyes.

Key Findings

• Cell Growth Variation: Relative cell growth rates adjusted with the angle of the SMFs, showing that changes in SMFs can both enhance and impede cell growth.
• Biochemical Changes: Increased SMF magnitude raised mitochondrial calcium and membrane potential, while decreasing intracellular pH.
• Oxidative Stress: Oxidative stress slightly increased with higher SMFs. Notably, concentrations of mitochondrial superoxide and nitric oxide generally decreased, whereas hydrogen peroxide levels showed complex variations, impacting cell proliferation and signaling.

Conclusion

The study confirms that weak SMFs bear a significant impact on cellular growth and biochemical states, which can have both beneficial and deleterious health effects on biological systems. This underlines the importance of further investigating the nuanced effects of electromagnetic fields on living tissues.