Abstract

Overview

The study investigates the anticancer effects of electromagnetic fields, specifically through a device that generates oscillating magnetic fields (OMF). This research was propelled by the need to understand mechanisms by which electromagnetic fields can target cancer cells, specifically glioblastoma (GBM).

Purpose

A novel device known as the Oncomagnetic Device was developed, generating OMF by rapidly rotating strong permanent magnets. This device was applied to treat a patient with end-stage recurrent GBM under compassionate use protocols.

Methods

• GBM cells, lung cancer cells, and various normal human cells were exposed to OMF.
• Control groups included unstimulated and sham-stimulated cells.
• Techniques like quantitative fluorescence microscopy were deployed to analyze cell morphology, viability, and mechanisms of ROS production.

Findings

OMF selectively induced apoptosis in GBM and lung cancer cells without harming normal tissues. This effect was associated with increased ROS levels within cell mitochondria, suggesting disruptions in mitochondrial electron flow as a potential mechanism.

Conclusion

The study confirms the potential of OMF from the Oncomagnetic Device in selectively targeting cancer cells through mechanisms involving elevated ROS levels, paving the way for non-invasive cancer treatments.