DNMT1 and miRNAs: possible epigenetics footprints in electromagnetic fields utilization in oncology

Authors: Mohadeseh Shayeghan, Flora Forouzesh, Alireza Madjid Ansari, Mohammad Amin Javidi

Year: 2021 Sep 8

Category: Oncology

Journal: Med Oncol

DOI: 10.1007/s12032-021-01574-y

URL: https://pubmed.ncbi.nlm.nih.gov/34495398/

Abstract

Abstract Summary

Overview

Research has extensively explored the effects of Electromagnetic fields (EMFs) on biological systems and their potential uses in medical applications, especially in oncology.

Findings

  • EMFs, particularly Extremely low frequency electromagnetic fields (ELF-EMF), have been studied for their role in epigenetically modulating cancer cells.
  • These fields interact with epigenetic mechanisms such as DNA methylation, histone modification, and miRNAs.
  • ELF-EMF exposure could influence various cellular processes like DNA repair, apoptosis, metastasis prevention, differentiation, and cell cycle regulation in cancer cells.

Conclusion

While ELF-EMF shows potential for use in cancer epigenetic therapy, the study emphasizes the need for further molecular and clinical research to ascertain its safe and effective dosimetric characteristics in practical applications.

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