Abstract

Overview

Many studies have investigated the effects of Electromagnetic fields (EMFs) on biological systems, particularly for medical applications in cancer therapy. Despite numerous studies showing the potential effectiveness of EMFs in pre-clinical cancer scenarios, the outcomes at the molecular level remain complex and challenging.

Findings

• The article focuses on the epigenetic mechanisms influenced by EMFs, especially Extremely low frequency electromagnetic fields (ELF-EMF).
• Epigenetic mechanisms, including DNA methylation, histone modification, miRNAs, and nucleosome remodeling, are reversible and susceptible to environmental factors, such as ELF-EMF exposures.
• ELF-EMF may impact DNA repair, apoptosis, metastasis prevention, differentiation, and cell cycle regulation through direct actions or via molecular signaling pathways.

Conclusion

The study indicates that ELF-EMF exposure might be beneficial in cancer epigenetic therapy. However, further molecular and clinical research is necessary to establish the safe and specific dosimetric characteristics of ELF-EMF for clinical use.