Abstract

Abstract Summary: Epigenetic Dysregulation Linked to ELF-MF Exposure

Overview

Epigenetic mechanisms play a crucial role in regulating gene expression without altering the DNA sequence. They are key to establishing cell-type-specific temporal and spatial expression patterns.

Findings

Research indicates that alterations in epigenetic marks can contribute to a range of pathological conditions such as cancer and neurological disorders. Various environmental factors, including extremely low-frequency magnetic fields (ELF-MFs), have been implicated in causing these epigenetic changes, potentially affecting disease susceptibility. Notably, ELF-MFs were classified as possible carcinogens by the International Agency for Research on Cancer in 2002.

This review synthesizes the extant research connecting ELF-MF exposure to epigenetic alterations in different cell types. Despite the relatively few studies, there is evidence suggesting that exposure to ELF-MFs may lead to significant modifications in DNA methylation, histone alterations, and microRNA expression.

Conclusion

Given the profound implications, this research area necessitates further investigation to elucidate the molecular mechanisms behind these observations and to understand the broader implications for public health.