Abstract

Overview

The purpose of this paper is to assess the evidence for and against the premise that hyperthermia is carcinogenic. This study was motivated by a World Health Organization workshop on health risks associated with hyperthermia, particularly in the context of RF field exposures.

Findings

• Discussion on the effects of heat on DNA damage/repair and mutations.
• Analysis of in vivo studies assessing the carcinogenic potential of heat both alone and when combined with other carcinogens.
• Evaluation of in vivo studies on RF exposures and their link to carcinogenesis.

The majority of data presented in the study suggests that hyperthermia alone does not cause cancer. It may modify the carcinogenic effects of other agents like radiation or chemical carcinogens under certain conditions. In certain scenarios, hyperthermia can prevent tumor development, while in others, it can increase tumor incidence—particularly when combined with significant doses of radiation or chemicals.

Conclusion

The conclusion is drawn that incidental RF exposures, like those from cell phones causing minimal temperature rises, are not carcinogenic. However, caution is advised when thermal exposures sufficient to cause tissue damage occur alongside exposure to known carcinogens. Further research is needed on the carcinogenic risks of chronic low-level thermal exposures, alone or with carcinogens.