Abstract

Overview

As electromagnetic technology progresses, artificial electromagnetic fields (EMFs), specifically Extremely-low-frequency (ELF) magnetic fields produced by power lines and various electric equipment, have become prevalent in our environment. These fields are recognized as possibly carcinogenic to humans according to the International Agency for Research on Cancer (IARC).

Findings

This study investigates the effects of 50 Hz magnetic fields at 1.0 mT for 24 hours on senescent and non-senescent human fetal lung fibroblasts. The findings reveal that exposure leads to significant DNA damage in senescent cells, highlighting their increased susceptibility compared to non-senescent cells. The study further identifies that the DNA damage is mediated by the activation of mitochondrial permeability transition pore (mPTP) and subsequent reactive oxygen species (ROS) generation.

Conclusion

While the study confirms the senescent cells' sensitivity to DNA damage from ELF magnetic fields and outlines a potential mechanism via mPTP activation, it suggests the need for further research to explore the implications for carcinogenesis.