Microarray profiling of LncRNA expression in the testis of pubertal mice following morning and evening exposure to 1800 MHz radiofrequency fields

Abstract

Overview

In a recent study, researchers explored the chronotoxic effects of 1800 MHz radiofrequency fields (RF) on the development of pubertal testis in mice. The mice were exposed to RF twice daily over three weeks to analyze changes in testis pathology and function.

Findings

• RF exposure resulted in a decrease in testicular weights, daily sperm production, and testosterone secretion.
• Pathological changes were notable in the testes following RF exposure.
• A significant number of differentially expressed lncRNAs were identified, which are linked to various biological pathways influencing testis development and spermatogenesis.
• An interaction network of lncRNAs was established, highlighting their role in transcription factor-regulated pathways.

Conclusion

The study indicates that RF exposure distinctly affects morning and evening exposure in terms of lncRNA expression in the testes. These findings enhance our understanding of the molecular pathways involved in the RF-associated toxic effects on the testicular development of pubertal mice.