Lung Cell Toxicity of Co-Exposure to Airborne Particulate Matter and Extremely Low-Frequency Magnetic Field

Authors: Zahra Panjali, Parviz Abdolmaleki, Behnam Hajipour, Omar Hahad, Rezvan Zendehdel

Year: 2022 May 24

Category: Toxicology

Journal: Xenobiotica

Institution: Xenobiotica

DOI: 10.1080/00498254.2022.2082342

URL: https://pubmed.ncbi.nlm.nih.gov/35608272/

Abstract

Abstract Summary

Overview: This study focuses on the less studied area of combined exposure to urban airborne particulate matter (PM) and extremely low frequency magnetic fields (ELF-MF) in workplace settings.

  • Findings: Exposure settings included total particulate matter (TPM) analyzed via NIOSH methods and 900 mG ELF-MF based on field measurements. Various toxicity mechanisms such as oxidative stress and DNA damage were evaluated using indicators like malondialdehyde levels and gene expression changes.
  • The effects of both isolated and combined exposure to TPM and ELF-MF on A549 human lung cells were examined.
  • Conclusion: The results demonstrated that while ELF-MF exposure might reduce the toxicity levels caused by TPM alone, the combined exposure still poses significant risks as indicated by the presence of oxidative stress and DNA damage. Despite the reduction, toxicity levels due to ELF-MF co-exposure remain significant and cannot be ignored.
toxicology ELF-MF particulate matter lung cells occupational health
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