Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events
Abstract
Overview
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are both natural byproducts of normal cellular operations and signals for intracellular processes. However, their significance is of concern due to their adverse responses connected with diseases and exposure to various stressors.
Findings
- Role of ROS and RNS: Collectively known as RONS, these molecules are essential in various adverse outcome pathways (AOPs), which are frameworks used to show causal relationships leading to disease or adverse health outcomes.
- Key Events in AOP: RONS can trigger key events in AOP cascades leading to adverse outcomes. However, they can also modulate other events in the AOP continuum without being classified as AOP events themselves.
- Impact of Various Stressors: The workshops titled "Mystery or ROS" focused on the interaction of RONS with various stressors, including nanoparticles, chemicals, and both ionizing and non-ionizing radiation, highlighting the potential health risks associated.
Conclusion
The review advocates for a harmonized approach within the AOP developer community, suggesting the need for a common event terminology to streamline research and understandings in this crucial area.