Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events
Abstract
Overview
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play significant roles in both normal cellular functions and adverse health outcomes. These species, collectively known as RONS (Reactive Oxygen and Nitrogen Species), are pivotal in many adverse outcome pathways (AOPs) which are essential for understanding disease progression and the impact of environmental stressors.
Findings
- RONS are crucial in signaling and natural cellular processes as well as in response to harmful stimuli.
- The study highlights the association of RONS with various diseases and adverse outcomes resulting from exposure to different stressors including chemicals and both ionizing and non-ionizing radiation.
- A series of workshops titled "Mystery of ROS" aimed to clarify the role of RONS in these pathways.
Conclusion
The review emphasizes the need for a harmonized terminology within the AOP framework to facilitate better understanding and communication among researchers across different fields. This approach will also aid in the more accurate depiction of RONS' roles in disease processes and adverse health outcomes.