Abstract

Abstract

Overview

Many articles describe the effects of extremely low-frequency magnetic fields (MF) on DNA damage induction. However, the mechanism of MF interaction with living matter remains uncertain. Some studies suggest that MF might enhance Reactive Oxygen Species (ROS) production efficacy.

Materials and Methods

• Substance and Measurement: Genomic DNA was prepared from S. cerevisiae cultures and subjected to various exposures.
• Pulsed Magnetic Field Conditions: DNA was exposed to a pulsed MF (1.5 mT peak, 25 Hz) along with MMS (0-1%) for 15-60 minutes, and with bleomycin (0-0.6 IU/ml) for 24-72 hours.

Findings

Pulsed MF has shown to increase the level of DNA damage produced by MMS and bleomycin under the tested conditions.

Conclusion

The study indicates that pulsed MF could modulate the cytotoxic actions of MMS and bleomycin, potentially due to a multifactorial process influenced by the type and dose of the DNA-damaging agent and the duration of exposure to the pulsed MF.