Impact of Mobile Phone Specific Electromagnetic Fields on DNA Damage Caused by Occupationally Relevant Exposures: Results of ex vivo Experiments with Peripheral Blood Mononuclear Cells from Different Demographic Groups

Authors: Mišík M, Kundi M, Worel N, Ferk F, Hutter HP, Grusch M, Nersesyan A, Herrera Morales D, Knasmueller S

Year: 2023 Jul 7

Category: Genetics, Radiobiology

Journal: Mutagenesis

DOI: 10.1093/mutage/gead022

URL: https://pubmed.ncbi.nlm.nih.gov/37418160/

Abstract

Overview

The study investigates the potential genotoxic effects of mobile phone-specific high-frequency electromagnetic fields (HF-EMF) and their interaction with occupational chemical exposures on human DNA.

Findings

  • Three demographic groups were analyzed: young normal weight, young obese, and older normal weight individuals.
  • Cells were exposed to HF-EMF with a specific absorption rate (SAR) of 0.25, 0.5, and 1.0 W/kg and to harmful chemicals like CrO3, NiCl2, benzo[a]pyrene diol epoxide (BPDE), and 4-nitroquinoline 1-oxide (4NQO).
  • No general impact of UMTS signals on chemically induced DNA damage across groups. However, a significant increase in DNA damage was observed in older individuals at a higher SAR level (1.0 W/kg).
  • A moderate decrease in DNA damage was noted in the young obese group when subjected to simultaneous exposure to BPDE and 1.0 W/kg SAR.

Conclusion

The study concludes that while HF-EMF can cause DNA damage in older individuals and does not generally exacerbate DNA damage from occupational chemicals, specific interactions, such as those seen in the young obese group, suggest a complex interplay of factors.

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