Abstract

Overview

Electromagnetic (EM) signals are commonly utilized in various electronic and biomedical systems and are inevitably present around humans, potentially impacting their health.

Research Objective

The study introduces a specially designed lab-on-chip featuring three-dimensional interdigital electrodes for observing cellular responses under EM stimulation. It aims to elucidate interactions between EM signals and biological structures.

Methodology and Findings

• A lab-on-chip prototype was developed using full-wafer microfabrication techniques.
• The device creates a controlled EM environment with field strengths reaching up to 4.45Vrms/m at a 10Vpp, 10 kHz input signal.
• Frequency range for effective observation was determined to extend up to 3 MHz.
• Prototype impedance was characterized between 20 Hz and 30 MHz.
• Human cell line HEK293T was cultured and observed for 24 hours to assess the biocompatibility and the influence of EM stimulation.

Conclusion

The findings confirm substantial effects of the 10 kHz EM signal on cell growth, suggesting potential health risks associated with exposure to similar EM environments in daily life.