The Effects of Prenatal and Postnatal Exposure to 50-Hz and 3 mT Electromagnetic Field on Rat Testicular Development

Authors: Ersoy N, Acikgoz B, Aksu I, Kiray A, Bagriyanik HA, Kiray M

Year: 2022 Dec 29

Category: Reproductive Biology

Journal: Medicina

Institution: Medicina (Kaunas)

DOI: 10.3390/medicina59010071

URL: https://www.mdpi.com/1648-9144/59/1/71

Abstract

Overview

This research explores the effects of exposure to electromagnetic fields (EMFs) of 50-Hz and 3 mT on the development of rat testes during both prenatal and postnatal periods.

Background and Objectives

The study investigates the controversial biological effects of EMF exposure on the male reproductive system, focusing specifically on the frequency and duration of exposure impacts.
A distinct emphasis is placed on understanding how prenatal and postnatal exposure to EMFs impacts testicular development.

Materials and Methods

Three groups of Sprague-Dawley rat offspring were analyzed, with variations in exposure timings up to postnatal days 28 and 42, alongside a control sham group.

Findings

Significant findings include a decrease in seminiferous tubule diameter in rats post exposure, indicative of testicular degeneration, notably in the group exposed till day 42.
Alterations in hormonal levels (FSH and LH) and increases in lipid peroxidation were observed, alongside decreases in antioxidant levels in the EMF-28 group.
Protein analyses showed lower levels of VEGF, IGF1, and SHANK3, highlighting potential mediation by these proteins in testis changes resulting from EMF exposure.

Conclusion

The study confirms potential health risks associated with EMF exposure, showing a causative correlation with structural deterioration and functional impairments in testicular development of male rat pups. It pinpoints significant oxidative stress and decreased protein levels as potential mediators of EMF-induced testicular damage.

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