Microarray profiling of LncRNA expression in the testis of pubertal mice following morning and evening exposure to 1800 MHz radiofrequency fields

Authors: Qin F, Cao H, Feng C, Zhu T, Zhu B, Zhang J, Tong J, Pei H

Year: 2021 Aug 8

Category: Chronobiology

Journal: Chronobiol Int

Institution: Chronobiol Int

DOI: 10.1080/07420528.2021.1962902

URL: https://pubmed.ncbi.nlm.nih.gov/34369206/

Abstract

Overview

This study explores the chronotoxic effects of radiofrequency (RF) fields on the development of the pubertal testis by exposing four-week-old mice to an 1800 MHz RF field. The specific absorption rate was maintained at 0.50 W/kg during the morning and evening sessions over a period of three weeks.

Findings

  • Pathological Changes: The exposure led to significant reductions in testicular weight, daily sperm production, and testosterone secretion.
  • LncRNA Dysregulation: Analysis identified differences in lncRNA expression profiles, with 615 and 183 lncRNAs differentially expressed due to morning and evening exposures, respectively.
  • Molecular Pathways: These lncRNAs were linked to several critical pathways such as Fanconi syndrome, metabolic processes, and DNA replication.
  • Trans-regulation: Further analysis showed involvement across multiple transcription factor-regulated pathways.

Conclusion

The study substantiates the potential health risks associated with RF exposure, highlighting its impact on testicular development and its capacity to induce differential expression of crucial lncRNAs. These findings underline the importance of understanding exposure timing in the context of RF-induced developmental toxicity.

radiofrequency fields lncRNA testicular development chronotoxicity spermatogenesis transcription factors pubertal mice
← Back to Stats