ZIP9-centered pathway compensates for radiofrequency radiation-mediated reduction in resistance to H2O2 damage in Sertoli cells of rats

Authors: Yu G, Zhu Y, Song C, Chen L, Tang Z, Wu T

Year: 2023 Mar 6

Category: Ecotoxicology

Journal: Ecotoxicol Environ Saf

Institution: Ecotoxicol Environ Saf

DOI: 10.1016/j.ecoenv.2023.114733

URL: https://pubmed.ncbi.nlm.nih.gov/36889209/

Abstract

Overview

The study explores the biological effects of 2605 MHz radiofrequency electromagnetic radiation (RF-EMR), focusing on its impact on Sertoli cells in rat testes and associated mechanisms.

Findings

  • RF-EMR exposure was shown to not decrease sperm quality or spermatogenesis in the short term.
  • However, it increased apoptosis in Sertoli cells exposed to oxidative stress (H2O2), with testosterone (T) ameliorating these effects.
  • The protective role of T was linked to increased levels of ZIP9 and an unfolded protein response in the cells.
  • Long-term exposure led to a decrease in ZIP9 levels and increase in malondialdehyde (MDA), suggesting progressive cellular damage.

Conclusion

Short-term RF-EMR exposure affects the ability of Sertoli cells to resist external insults, but this can be compensated by enhancing the ZIP9-centered androgen pathway. This insight is critical for understanding the nuanced reproductive toxicity associated with prolonged RF-EMR exposure.

RF-EMR testosterone ZIP9 spermatogenesis Sertoli cells reproductive toxicity electromagnetic radiation
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