Extremely low-frequency electromagnetic field induces acetylation of heat shock proteins and enhances protein folding

Authors: Huang Z, Ito M, Zhang S, Toda T, Takeda JI, Ogi T, Ohno K

Year: 2023 Sep 15

Category: Ecotoxicology

Journal: Ecotoxicol Environ Saf

DOI: 10.1016/j.ecoenv.2023.115482

URL: https://www.sciencedirect.com/science/article/pii/S0147651323009867

Abstract

Overview

The study investigates the effects of extremely low-frequency electromagnetic fields (ELF-EMF) on heat shock proteins (HSPs) and cellular functions.

Findings

  • ELF-EMF at 10 µT induces mitochondrial hormesis, revealed through various experiments in AML12 and HEK293 cells.
  • Significant acetylation of HSP70 and HSP90 at 3 hours and their enhanced binding to HOP/STIP1.
  • Reduction in mitochondria mass and simultaneous increase in maximal oxygen consumption and ATP levels.
  • Overall, ELF-EMF exposure reduced protein aggregates and enhanced cell viability.

Conclusion

The application of ELF-EMF can activate acetylation of HSPs, improve protein folding, and potentially treat pathological states, though the effect returned to basal level after 12 hours.

ELF-EMF heat shock proteins protein folding cell viability mitochondria oxygen consumption
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