Inhibition of mitochondrial calcium uptake by Ru360 enhances the effect of 1800 MHz radio-frequency electromagnetic fields on DNA damage

Authors: Sun C, Zhu L, Qin H, Su H, Zhang J, Wang S, Xu X, Zhao Z, Mao G, Chen J

Year: 2023 Sep 14

Category: Ecotoxicology

Journal: Ecotoxicology and Environmental Safety

DOI: 10.1016/j.ecoenv.2023.115472

URL: https://www.sciencedirect.com/science/article/pii/S0147651323009764

Abstract

Overview

The study explores the effects of 1800 MHz radio-frequency electromagnetic fields (RF-EMF), a common type of radiation emitted from devices like cell phones and wireless routers, on cellular health. Concerns about the increasing exposure to RF-EMF and its potential health risks are growing.

Findings

  • Enhanced DNA Damage: Using Ruthenium 360 (Ru360), an inhibitor of mitochondrial calcium uptake, DNA damage and apoptosis in mouse embryonic fibroblasts (MEFs) are significantly increased under short-term RF-EMF exposure.
  • Cellular Mechanisms: The interaction between mitochondrial dysfunction — induced by Ru360 — and RF-EMF exposure underscores potential cellular mechanisms liable for increased genotoxicity.
  • Cellular Repair: Damages induced by RF-EMF in Ru360 treated cells were quickly repaired within one hour post-exposure, raising questions about long-term effects and cumulative exposure.

Conclusion

Findings underscore an urgent need for deeper investigation into how mitochondrial calcium inhibitors like Ru360 influence the health impacts of RF-EMF exposure, particularly in the context of its genotoxicity. Increased scrutiny of RF-EMF exposure effects in medical treatments and everyday device use is recommended.

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