Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm-/- mouse embryonic fibroblasts

Authors: Sun C, Wei X, Fei Y, Su L, Zhao X, Chen G, Xu Z

Year: 2016 Nov 18

Category: Biophysics, Genetics

Journal: Sci Rep

Institution: Sci Rep

DOI: 10.1038/srep37423

URL: https://www.ncbi.nlm.nih.gov/pubmed/27857169?dopt=Abstract

Abstract

Overview

This study investigates the genotoxic effects of radiofrequency electromagnetic fields (RF-EMFs), which have been classified as possible carcinogens by the International Agency for Research on Cancer, focusing on their impact on genomic DNA in mouse embryonic fibroblasts (MEFs).

Findings

  • Subjects and Methods: The effects of 1,800 MHz RF-EMF exposure were compared in MEFs proficient (Atm+/+) or deficient (Atm-/-) in Ataxia telangiectasia mutated (ATM), an essential protein for genomic stability.
  • Results in Atm+/+ MEFs: Exposure to RF-EMF (average special absorption rate of 4.0 W/kg) for 1 hour induced significant DNA single-strand breaks (SSBs) and activated DNA repair mechanisms. Post-36 hours of exposure, DNA damage was notably reduced below background levels.
  • Results in Atm-/- MEFs: Prolonged exposure (12 hours) led to both SSBs and double-strand breaks, with subsequent activation of repair processes reducing DNA damage below control levels.

Conclusion

The observed effects suggest a hormesis-like response to RF-EMF exposure in MEFs, representing a low-dose beneficial effect despite the substance being potentially toxic, marking the first study reporting such a phenomenon.

RF-EMF carcinogens DNA damage genomic stability ATM hormesis mouse embryonic fibroblasts
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