Abstract

Effects of 50 Hz Magnetic Fields on Human Cells

Overview: The study delves into the biological effects and underlying mechanisms of extremely low frequency magnetic fields (ELF-MFs), identified by the International Agency for Research on Cancer (IARC) as potential carcinogens.

Methods: Investigating 50 Hz sinusoidal magnetic fields at different intensities (0-4.0 mT), phase-interrogation surface plasmon resonance (SPR) sensing was utilized to observe changes in the permittivity of cell culture medium. Subsequent cellular analyses included assessments of cell viability, oxidative stress levels, MAPK signaling pathway activation, and genetic stability via various bio-assays.

Findings: Results highlighted a reduction in SPR signals under magnetic field exposure, dependent on time and dosage, and reversible upon ceasing exposure. Despite these physical changes in the medium, there were no significant impacts on cell viability, intracellular oxidative stress, MAPK signaling, or genetic integrity in human amniotic epithelial cells.

Conclusion: The study concludes that although 50 Hz magnetic field exposure alters the physical properties of the cell culture medium (specifically permittivity), these changes do not lead to biological effects in amniotic epithelial cells. Thus, indicating a lack of direct risk under the tested conditions yet drawing attention to the broader implications and possible health risks ELF-MFs pose.