Permeability enhancement of Kv1.2 potassium channel by a terahertz electromagnetic field

Authors: Zhao X, Ding W, Wang H, Wang Y, Liu Y, Li Y, Liu C

Year: 2023 Jul 28

Category: Biophysics

Journal: J Chem Phys

DOI: 10.1063/5.0143648

URL: https://pubmed.ncbi.nlm.nih.gov/37486058/

Abstract

Overview

The influence of terahertz electromagnetic fields on biological systems, particularly ion channels, is of significant interest due to their fundamental role in biological electrical signaling. This study focuses on the impact of such fields on the permeability of the Kv1.2 potassium ion channel.

Findings

  • The study utilized molecular dynamics simulations to examine the effects at three terahertz frequencies: 6 THz, 15 THz, and 25 THz.
  • It was found that a 15 THz electromagnetic field notably enhances the channel's permeability—up to 1.7 times compared to the absence of an electromagnetic field.
  • Analysis of water molecule behavior indicated that the 15 THz frequency affects the duration of frozen and relaxation processes during potassium ion transit, favoring increased permeability through a direct knock-on mechanism.

Conclusion

This research underscores the profound capabilities of terahertz electromagnetic fields to modulate ion channel functions, which could have critical implications for understanding cellular processes and potential health risks associated with electromagnetic field exposure.

electromagnetic field ion channels molecular dynamics terahertz Kv1.2 potassium channel health risks
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