Abstract

Overview

In this paper, we explore the effect of external electromagnetic fields at terahertz (THz) frequencies on the permeability of the Kv1.2 voltage-gated potassium ion channels. This research utilizes the "Constant Electric Field-Ion Imbalance" method combined with molecular dynamics simulations.

Findings

The study shows that even though there is no strong resonance between the applied THz electromagnetic field and the amino acid residues in the channel, the field impacts the stability of crucial electrostatic and hydrogen bonds within the channel. Specifically:

• At a frequency of 15 THz, the stability of the hydrogen bond at the channel entrance is reduced by 29%.
• The probability of the "soft knock-on" ion permeation mode decreases by 46.9%.
• There is a significant activation of ion flux by 67.7%, compared to conditions without an external electric field.

Conclusion

These findings indicate that THz electromagnetic fields can modulate ion channel activity, potentially leading to alterations in cell function and health outcomes. This underscores the importance of further investigating the safety implications of THz field exposure, particularly in the context of its potential effects on biological systems and disease conditions.