Exposure to a static magnetic field attenuates hepatic damage and function abnormality in obese and diabetic mice

Authors: Lv H, Wang Y, Liu J, Zhen C, Zhang X, Liu Y, Lou C, Guo H, Wei Y

Year: 2023 Apr 26

Category: Molecular Biology

Journal: Biochim Biophys Acta Mol Basis Dis

DOI: 10.1016/j.bbadis.2023.166719

URL: https://pubmed.ncbi.nlm.nih.gov/37116230/

Abstract

Overview

Recent research has unveiled the significant impact of Static Magnetic Fields (SMFs) on healthcare, particularly focusing on their effects in the realm liver metabolism in conditions such as obesity and diabetes. The liver, pivotal in glucolipid and iron metabolism, has shown a varying response to SMF exposure.

Methodology

In the study, obese and diabetic mice were subjected to a moderate-intensity SMF varying between 0.4 to 0.7 Tesla in an upward direction for four hours per day over an eight-week period.

Findings

  • SMF exposure resulted in a reduction of hepatic damage, evidenced by decreased inflammation and fibrosis levels in diabetic and obese mice.
  • While not improving glucose or insulin tolerance significantly, SMF affected several proteins and genes associated with glucose metabolism.
  • Decreased lipid accumulation and earlier mentioned protein effects suggest an enhancement in lipid metabolism in response to SMF.
  • Crucial reductions in hepatic iron deposition alongside regulated systemic iron homeostasis were noted.
  • Improvements in redox status and mitochondrial function due to SMF were observed.
  • The activation of hepatic autophagy and enhanced lipophagy indicated a comprehensive approach by SMF in managing liver health.

Conclusion

This study indicates that SMF can significantly reduce hepatic injury in diabetic and obese mice by managing inflammation, optimizing glycolipid metabolism, regulating iron balance, and promoting autophagy. Proximity to electromagnetic fields may have a noteworthy implication in managing hepatic issues related to diabetes and obesity.

static magnetic fields hepatic damage diabetes obesity magnetic field therapy
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