Abstract

Overview

The tumor-treating fields (TTFields) technology has significantly influenced the management strategies for recurrent and newly diagnosed glioblastoma cases. This study aims to enhance TTFields' effectiveness for glioblastoma and other cancers.

Methodology and Findings

This research entails a detailed biophysical analysis of electromagnetic exposure with varying frequencies and electric field strengths on cells during mitosis, focusing particularly on the telophase stage. We developed an intuitive finite element model of the mitotic cell for electromagnetic simulations. This model predicted a local increase in activity in the cleavage furrow region, potentially elucidating TTFields' mechanism preventing cell proliferation.

Further, cell experiments confirmed that TTFields reduces glioma cell proliferation and migration in a frequency- and field-strength-dependent manner, marking a significant observation for clinical settings.

Conclusion

The insights gathered from selecting specific frequencies for TTFields application could pioneer improved therapeutic strategies against tumors, offering a significant advancement in non-invasive cancer treatments.