Trends and patterns of incidence of diffuse glioma in adults in the United States, 1973-2014

Abstract

Overview

The study focused on identifying the trends in the incidence of adult diffuse gliomas in the United States over a prolonged period and sought to decipher the role of age, period, and cohort effects on these trends.

Methods

• Employed data from the Surveillance, Epidemiology, and End Results 9 database.
• Targeted primary diffuse glioma patients diagnosed from 1973 to 2014.
• Utilized joinpoint regression and age-period-cohort modeling to analyze incidence trends.

Findings

The incidence of adult glioma showed a slow decrease from 1985 to 2014. Specifically, glioblastoma incidence increased over the studied periods, whereas nonglioblastoma incidence decreased significantly. Distinct cohort and period effects were noted, demonstrating varied risks based on the era and cohort groupings, accentuating the complexity of glioma incidence.

Conclusion

The observed differing trends across glioma subtypes suggest an underlying etiological heterogeneity, pointing to the need for further focused epidemiological studies to thoroughly understand these discrepancies in incidence trends.