Antitumor effect of static and ELF MF against nephroblastoma and neuroblastoma

Authors: Yuan LQ, Wang C, Zhu K, Li HM, Gu WZ, Zhou DM, Lai JQ, Zhou D, Lv Y, Tofani S, Chen X

Year: 2018 May 2

Category: Bioelectromagnetics

Journal: Bioelectromagnetics

DOI: 10.1002/bem.22124

URL: https://www.ncbi.nlm.nih.gov/pubmed/29719057

Abstract

Overview

This study evaluates the antitumor effects of static and extremely low frequency (ELF) magnetic fields (MF) against common childhood malignancies, particularly nephroblastoma and neuroblastoma.

Methodology and Findings

  • A well-characterized MF with a total intensity of 5.1 millitesla (mT) was applied; composed of a static and an ELF component (50 Hz).
  • The MF treatments were administered for 2 hours daily.
  • Significant reductions in cell viability were observed, with 17-22% inhibition rates in cell lines after 3 days of exposure.
  • Inhibition was positively associated with exposure duration. Combination treatments using MF and cisplatin showed further increased inhibition rates.
  • In vivo, in a G401 nephroblastoma tumor model in nude mice, the combination treatment significantly reduced tumor mass with limited side effects.

Conclusion

The research confirmed the antitumor potential of MF, particularly when combined with chemotherapeutic agents, highlighting its suitability as a supportive treatment for nephroblastoma and neuroblastoma.

antitumor effect magnetic fields nephroblastoma neuroblastoma ELF magnetic fields
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