Abstract

Abstract

Overview

The tumor-treating fields (TTFields) technology has been instrumental in the advanced management of both recurrent and newly diagnosed cases of glioblastoma (GBM).

Findings

• The study delved into understanding the biophysical principles of TTFields to enhance treatment modalities for GBM and similar oncological conditions.
• Analysis was conducted on the impact of electromagnetic exposure with varying frequencies and electric field strengths on cells specifically in the mitotic phase, focussing on telophase.
• A finite element model of the mitotic cell was developed to enable electromagnetic simulations, showing a local increase in the cleavage furrow region, contributing to TTFields' anti-proliferative effects.
• Cell experiments validated that reduction in proliferation and migration of glioma cells through TTFields is dependent on frequency and field strength.

Conclusion

This research provides critical insights into the selection of frequencies that optimize the anti-proliferative effect of TTFields on tumors, suggesting improvements in the application of this treatment.