Glioblastoma Cell Migration is Directed by Electrical Signals

Abstract

Overview

Research suggests that electric fields (EFs) influence cell migration in glioblastoma multiforme (GBM) and neural stem cells. This study focuses on migration patterns in response to EFs and possible interventions.

Findings

• Electrotaxis in GBM: Electrotaxis, or EF-directed migration, exhibits varied patterns between primary differentiated GBM cells and glioma stem cells (GSCs). Differentiated cells show a preference for anodal migration, while GSCs tend to migrate cathodally.
• Experimental Intervention: The study investigated the effect of the PPARγ agonist pioglitazone on electrotaxis by chemically disrupting Akt via PTEN upregulation. Results indicate that pioglitazone significantly inhibits cell migration in both cell types. Interestingly, Pioglitazone did not alter PPARγ expression.

Conclusion

The opposing migration responses under EF exposure can be chemically inhibited using pioglitazone, suggesting a novel approach to potentially prevent tumor recurrence by modulating GBM's electrotactic behaviors.