Abstract

Abstract Summary of the Study

Overview

The objective of the study was to assess the efficacy and safety of tumor-treating fields (TTFields) in conjunction with radio chemotherapy compared to conventional radio chemotherapy alone for treating glioblastoma.

Methods

• Systematic Review: Literature search conducted across PubMed, Cochrane Library, and Scopus databases.
• Study Selection: Adhered to PRISMA guidelines, with six studies qualifying for both qualitative and quantitative analysis.

Findings

• Survival Benefits: Significant improvement in median overall survival and progression-free survival observed in patients treated with TTFields.
• Survival Rates: Enhanced survival at 1 and 2 years, and comparable survival at 3 years with TTFields.
• Safety: TTFields exhibited fewer adverse events compared to conventional methods, despite similar rates of skin irritation.

Conclusion

TTFields have proven to be a novel, efficient, and safer treatment method for glioblastoma. The study highlights the need for further larger and randomized controlled trials to establish long-term benefits of TTFields.