Abstract

Overview

The study explores the utilization of reactive oxygen species (ROS) elevation in cancer cells, focusing on glioma cells, to induce cell death as a potential anticancer treatment. This involves the development of a new portable wearable electromagnetic field (EMF) device.

Findings

• The introduced device generates spinning oscillating magnetic fields (sOMF) targeting selective oncolysis in cancer cells, sparing normal cells.
• Effective both in vitro and in shrinking glioma-based tumors in vivo via a novel biological mechanism.
• Detailing the configurations and timing of sOMF that lead to increased superoxide levels causing cytotoxic effects.
• Impact of antioxidant Trolox on reversing these effects, confirming ROS's role in the observed anticancer activity.

Conclusion

The study provides a clearer understanding of the link between the physical properties of magnetic stimulation and its anticancer effects, supporting the development of new noninvasive treatments for gliomas and potentially other cancers.