Is extremely low frequency pulsed electromagnetic fields (EMF) applicable to gliomas? A literature review of underlying mechanisms and application of extremely low frequency pulsed EMF

Authors: Huang M, Li P, Chen F, Cai Z, Yang S, Zheng X, Li W

Year: 2022 Aug 5

Category: Oncology

Journal: Cancer Med

DOI: 10.1002/cam4.5112

URL: https://onlinelibrary.wiley.com/doi/10.1002/cam4.5112

Abstract

Overview

Gliomas are complex brain tumors characterized by a low 5-year survival rate and limited therapeutic options. Extremely low-frequency pulsed electromagnetic field (ELF-PEMF) therapy, which has negligible side effects, is discussed in this context.

Findings

  • Calcium ions: Interaction of calcium ions with ELF-PEMF and its implications.
  • Autophagy: Influence of ELF-PEMF on autophagic processes in cells.
  • Apoptosis: Induction of apoptosis in glioma cells through ELF-PEMF.
  • Angiogenesis: Changes in angiogenesis triggered by ELF-PEMF.
  • Reactive oxygen species: ROS generation and its relationship with ELF-PEMF exposure.

The specific applications of ELF-PEMF in clinical practices and its prospects in combination with conventional therapies are elaborated.

Conclusion

While ELF-PEMF therapy is rarely applied in glioma treatment, the reviewed mechanisms and combined therapy approaches indicate potential benefits for patient care, especially underlining its safety. This information is crucial for specialists, primarily oncologists, examining innovative and supplementary treatments for gliomas.

gliomas electromagnetic fields ELF-PEMF oncology cancer treatment brain tumors health risk
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