Amplitude-modulated RF EMF blocks growth of hepatocellular carcinoma via voltage-gated calcium channels and calcium ion influx

Authors: Jimenez H, Wang M, Zimmerman JW, Blackman CF, Pasche BC

Year: 2019 May 24

Category: Oncology

Journal: EBioMedicine

Institution: Wake Forest Baptist Comprehensive Cancer Centre

DOI: 10.1016/j.ebiom.2019.05.034

URL: https://www.ebiomedicine.com/article/S2352-3964(19)30342-1/fulltext

Abstract

Overview

The administration of 27·12 MHz amplitude-modulated radiofrequency electromagnetic fields (AM RF EMF), using a novel intrabuccal application, has emerged as a promising treatment for advanced hepatocellular carcinoma (HCC). This abstract outlines the novel application method and its underlying mechanisms.

Methods

Comprehensive dosimetry analyses focusing on whole-body and organ-specific exposure were performed.
Mice carrying human HCC xenografts were treated using a small animal AM RF EMF system replicating human exposure conditions.
The effects on HCC were analyzed histologically post-exposure.
Genomic techniques were utilized to unravel the interaction mechanisms of AM RF EMF.

Findings

AM RF EMF, administered intrabuccally, delivers systemic athermal exposure which contributes to the tumor shrinkage by differentiating HCC cells into a quiescent state. A key mechanism involves the influx of Ca2+ through specific Cav3.2 T-type voltage-gated calcium channels leading to changes in intracellular calcium levels in the HCC cells solely.

Conclusion

The method shows significant potential in selectively inhibiting HCC cell growth and impacting cancer stem cells, which may explain the prolonged positive outcomes in treated patients.

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