Effects of ELF-PEMF exposure on spontaneous alternation, anxiety, motor co-ordination and locomotor activity of adult wistar rats and viability of C6 (Glial) cells in culture

Authors: Tekam CKS, Majumdar S, Kumari P, Prajapati SK, Sahi AK, Shinde S, Singh R, Samaiya PK, Patnaik R, Krishnamurthy S, Mahto SK

Year: 2022 Dec 24

Category: Toxicology

Journal: Toxicology

DOI: 10.1016/j.tox.2022.153409

URL: https://pubmed.ncbi.nlm.nih.gov/36572170/

Abstract

Overview

The study investigated the effects of Extremely Low Frequency-Pulsed Electromagnetic Fields (ELF-PEMF) on both in vitro and in vivo models. Specifically, it examined the impact of ELF-PEMF on wistar rats and C6 glial cells in culture.

Findings

  • ELF-PEMF exposure was set at 1-3 mT, 50 Hz, for two sessions of 20 minutes each with a four-hour interval.
  • No significant impact on cellular fragmentation or morphology changes in glial cells was reported.
  • Behavioral assessments showed no noticeable effects on anxiety, motor coordination, and locomotor activity, comparing exposed groups to control.
  • At the highest exposure level (3 mT), no undesirable side effects were observed.
  • Further histological analysis of the hippocampus and cortex revealed no substantial changes in cell count or tissue structure.

Conclusion

The research suggests that short-term exposure to ELF-PEMF, under the specified conditions, does not induce significant cellular or behavioral changes, indicating a potentially safe threshold for electromagnetic exposure.

ELF-PEMF glial cells motor coordination anxiety behavioral study
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