Abstract

Overview

Modern life exposes us to various frequencies of radiofrequency electromagnetic radiation (RF-EMR), but their health impacts remain unclear. This study explores the emotional effects of RF-EMR in mice exposed at specific frequencies and power levels.

Experimental Setup

• Mice were exposed to 0.9/1.5/2.65 GHz RF-EMR
• Exposure level set at 4 W/kg for 2 hours per day
• Duration: 4 weeks

Findings

The exposed mice demonstrated signs of anxiety without severe depression. Notable changes in biomarkers were observed:

• Decrease in amino acid neurotransmitters (GABA, DA, 5-HT)
• No significant change in acetylcholine (ACH) levels
• Increase in BDNF, TrkB, and CREB levels in the cerebral cortex
• Decrease in NF-κB levels
• Increased pro-inflammatory factors (IL-6, IL-1β, TNF-α)
• Decrease in anti-inflammatory factors (IL-4, IL-10)

Conclusion

Multi-frequency RF-EMR induces an inflammatory response through the CREB-BDNF-TrkB and NF-κB pathways in the cerebral cortex. This response leads to a reduction in excitatory neurotransmitters, thereby causing anxiety in mice. Future studies are encouraged to explore the specific mechanisms further and to confirm these findings.