Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study

Authors: Geronikolou SA, Vasdekis V, Mantzou A, Davos C, Cokkinos DV, Chrousos GP

Year: 2023 Jan 30

Category: Neuroscience

Journal: Children (Basel)

DOI: 10.3390/children10020248

URL: https://www.mdpi.com/2227-9067/10/2/248

Abstract

Overview

This pilot repeated measures study investigates the responses of the autonomic nervous system (ANS) and the hypothalamic–pituitary–adrenal (HPA) axis during consecutive extrinsic stimuli in healthy schoolchildren.

Methods

  • Participants: Twenty healthy children and adolescents aged 11–14 years
  • Procedures: Participants were exposed to an oral task, an arithmetic task, and a cellular phone call, each of different durations.
  • Measurements: Salivary cortisol and serum high-sensitivity C-reactive protein (hsCRP) were measured at baseline and after each stimulus.

Findings

The ANS and HPA axis responded differently to each stimulus. Key findings include:

  • Negative correlation between baseline hsCRP and cortisol
  • Varying ANS complexity and adaptation across stimuli
  • Baseline hsCRP and cortisol influencing the HPA axis over time

Conclusion

Low-level inflammation does not affect ANS dynamics, but it does impact how the HPA axis responds to external stimuli. This study highlights important aspects of physiological adaptations to environmental factors, including potential risks associated with electromagnetic fields.

neuroendocrine system autonomic nervous system hypothalamic-pituitary-adrenal axis inflammation EMF safety
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