Abstract

Overview

The study explores the influence of an external extremely low frequency (ELF) magnetic field and internal stressor, global cerebral ischemia, on the neuroendocrine system through their effects on pituitary adrenocorticotrophic (ACTH) and thyrotrophic (TSH) cells in young gerbils.

Methodology

• Exposure to a 50 Hz magnetic field averaging 0.5 mT over 7 days.
• Global cerebral ischemia induced for 10 minutes.
• Assessments conducted on both the 7th and 14th days post-experiment initiation.

Findings

Here are the significant findings from the study:

• ACTH cells: Both stressors reduced volume density significantly. Combined, they also increased intracellular ACTH content and plasma concentrations by day 7.
• TSH cells: The ELF magnetic field alone raised serum TSH concentration by day 7 and intracellular TSHβ content by day 14. In combination with ischemia, TSHβ content increased further on day 14.

Conclusion

The study concludes that both an ELF magnetic field and a brief period of cerebral ischemia can induce both immediate and delayed responses in ACTH and TSH synthesis and secretion, highlighting the sensitivity of the neuroendocrine system to electromagnetic fields and ischemic conditions.