Abstract

Overview

The study investigates the influence of 60 Hz 0.8 mT extremely low-frequency electromagnetic fields (ELF-EMF) on a macrophage cell line, RAW 264.7. There is a significant concern about the impact of electromagnetic waves due to the proximity of people to various electronic devices.

Findings

• Increased production of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 was observed.
• Nitric oxide production and expression of relevant genes were also upregulated under ELF-EMF exposure.
• Significant translocation of NF-κB to the nucleus and heightened activation of NFAT2 were noted, suggesting altered cellular signaling.
• ELF-EMF exposure led to enhanced calcium influx.
• Antioxidant capacity was diminished, as evidenced by the interaction of ELF-EMF with Resveratrol and the reduced expression of the antioxidant gene Prx-1.

Conclusion

The exposure to ELF-EMF may amplify inflammatory responses in macrophages and reduce the effectiveness of antioxidants, potentially disturbing cellular homeostasis and contributing to health risks.