Chronic blue light leads to accelerated aging in Drosophila by impairing energy metabolism and neurotransmitter levels

Abstract

Overview

Blue light (BL) is increasingly prevalent in artificial lighting and poses potential health risks. Acute BL exposure has been linked to oxidative stress and cell death in retinal cells. This study explores effects of chronic BL exposure on aging in Drosophila melanogaster.

Findings

• Chronic BL leads to accelerated aging, affecting flies even without specialized light-perceiving eyes.
• Impaired mitochondrial function and altered metabolic pathways suggest deep physiological impacts.
• Significant changes in metabolite levels were observed, particularly after 14 days of BL exposure, indicating serious energy production impairments.
• Detectable onset of neurodegeneration and lowered neurotransmitter levels reveal that BL disrupts brain homeostasis.

Conclusion

Chronic exposure to BL has severe implications for cellular health across species, impacting vital metabolic pathways and brain functions. Our findings highlight the urgent need for further research on the pervasive effects of blue light exposure in humans.

Considering the link between BL and aging phenomena, there is an inherent risk to human health that should not be underestimated.

Available online

This research is open access and can be fully accessed here.