Magnetic Fields Modulate Blue-Light-Dependent Regulation of Neuronal Firing by Cryptochrome

Authors: Giachello CN, Scrutton NS, Jones AR, Baines RA

Year: 2016 Oct 19

Category: Neuroscience

Journal: J Neurosci

URL: https://www.ncbi.nlm.nih.gov/pubmed/27798129?dopt=Abstract

Abstract

Overview

Many animals utilize Earth's geomagnetic field for behaviors like migration. The activation and modulation of the cryptochrome (CRY) protein by geomagnetic fields are theorized as key mechanisms influencing animal navigation.

Findings

  • It is demonstrated that photoactivation of CRY by blue light (BL) leads to depolarization and activation of Drosophila neurons. This effect is significantly enhanced when an external magnetic field (MF) of 100 mT is applied.
  • Electrophysiological studies on motoneurons show that both membrane potential depolarization and input resistance are amplified under MF, thereby increasing neuron action potential firing.
  • Detailed studies indicate CRY structural changes induced by MF align with behavioral adjustments in Drosophila, supporting the magnetic sense hypothesis.

Conclusion

The study furnishes direct experimental backing for the assertion that magnetic field exposure modulates CRY activity, which in turn affects neuronal action potential firing, suggesting a substantial role of CRY in animal magnetoreception and behavior alteration under magnetic influences.

magnetoreception cryptochrome neuronal activity magnetic fields electrophysiology Drosophila blue light
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