Changes in intracellular calcium concentration level accompany age-related inhibitions of Long-term potentiation in hippocampus induced by Extremely low frequency electromagnetic fields

Authors: Zhao W, Dong L, Tian L, Zhao L, Zhao Y, Zheng Y

Year: 2023 May 18

Category: Neuroscience

Journal: Eur J Neurosci

DOI: 10.1111/ejn.16046

URL: https://pubmed.ncbi.nlm.nih.gov/37203290/

Abstract

Overview

Extremely low frequency electromagnetic fields (ELF-EMFs) have recently garnered increased attention due to their impact on cognitive functions such as learning and memory. This study focuses on early developmental stages and the effects of ELF-EMFs on synaptic functions.

Findings

  • The study utilized electrophysiological methods to examine the persistence of Long-term potentiation (LTP) in the hippocampal CA1 region of Sprague-Dawley rats aged 8, 15, 22, and 29 days.
  • Results indicate that ELF-EMFs have a differential impact on LTP persistence, which is more pronounced in younger rats.
  • A notable reduction in LTP inhibition was observed with the blockade of IP3 receptors using 2-Aminoethoxydiphenyl borate (2-APB), implicating the role of intracellular calcium stores in the modulation of synaptic plasticity by ELF-EMFs.
  • Variations in extracellular calcium concentrations could either negate or enhance the inhibitory effects of ELF-EMFs on LTP, depending on the age of the subjects.

Conclusion

The findings underscore the complex regulatory effects of ELF-EMFs on synaptic plasticity, mediated through intracellular calcium pathways. These insights advocate for a more cautious and informed approach to the application and safeguards surrounding ELF technology, highlighting potential risks and considerations for health and biological development.

ELF-EMFs synaptic plasticity hippocampus LTP inhibition intracellular calcium electrophysiology age-related effects
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