Static electric field inhibits the proliferation and secretion functions of splenic lymphocytes in mice

Authors: Dong L, Wu J, Di G

Year: 2023 Apr 18

Category: Environmental Health Research

Journal: Int J Environ Health Res

Institution: Int J Environ Health Res

DOI: 10.1080/09603123.2023.2202900

URL: https://pubmed.ncbi.nlm.nih.gov/37070850/

Abstract

Overview

The study explores the impact of static electric fields (SEF) from ultra-high voltage (UHV) direct current (DC) transmission lines, an increasingly public health concern.

Findings

  • Exposure to 56.3 ± 1.4 kV/m SEF over 28 days significantly altered various biomarkers in mice.
  • Significant decreases in IL-10 and IFN-γ, important cytokines, and in the proliferation levels of splenic lymphocytes.
  • Increased superoxide dismutase (SOD) activity was observed, indicating changes in antioxidant responses.
  • Noticeable cellular damage included mitochondrial deficits and vacuolization, with adverse effects on T lymphocytes resulting in their death.

Conclusion

This study illustrates the detrimental effects of SEF on splenic lymphocyte function and mitochondrial integrity, emphasizing the potential risks of exposure to electromagnetic fields from transmission lines.

electromagnetic fields health risks lymphocyte function static electric fields mitochondrial damage
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