Comparison of ELF-EMFs stimulation with current stimulation on the regulation of LTP of SC-CA1 synapses in young rat hippocampus

Authors: Yu Zheng, Wenjun Zhao, Xiaoxu Ma, Lei Dong, Lei Tian, Mei Zhou

Year: 2021 May 10

Category: Neuroscience

Journal: Int J Radiat Biol

Institution: Int J Radiat Biol

DOI: 10.1080/09553002.2021.1928781

URL: https://pubmed.ncbi.nlm.nih.gov/33970763/

Abstract

Overview

Long-term potentiation (LTP) serves as a crucial marker in the research of synaptic plasticity. This study introduces a comparison between extremely low frequency electromagnetic fields (ELF-EMFs) and induced current's influence on LTP regulation.

Methodology

A novel approach for calculating the induced currents from ELF-EMFs is proposed.
Two ELF-EMFs settings (100 Hz/2 mT and 200 Hz/2 mT) and current stimulations (0.1 μA and 0.2 μA) were compared in their ability to regulate theta-burst or high-frequency stimulation-induced LTP.

Findings

Both types of stimulation notably diminished LTP in comparison to control groups.
100 Hz/2 mT ELF-EMFs showed stronger regulatory effects than 200 Hz/2 mT.
Similar effects were observed at 0.1 μA and 100 Hz/2 mT, while 0.2 μA exerted a stronger influence than 200 Hz/2 mT.

Comparison with Existing Methods

Unlike traditional approaches focused on human models, this study establishes a rat-brain slice model for better accuracy in ELF-EMFs induced current calculation.

Conclusion

The findings articulate that ELF-EMFs not only affect synaptic activity by inducing currents but also involve other magnetic mechanisms, suggesting a direct health risk impact of ELF-EMFs on biological tissues.

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