Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts

Authors: Sun Chuan, Huang Zheng, Qin Houbing, Zhang Jing, Wang Sanying, Xu Xiaogang, Ying Shibo, Mao Genxiang

Year: 2021

Category: Public Health

Journal: Frontiers in Public Health

Institution: Frontiers in Public Health

DOI: 10.3389/fpubh.2021.761069

URL: https://www.frontiersin.org/article/10.3389/fpubh.2021.761069

Abstract

Overview

Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is significantly influenced by both genetic and external factors. Electromagnetic fields (EMFs), whose usage is rapidly expanding, are one such external factor.

Findings

  • The effect of electromagnetic fields on aging and specifically cellular senescence, a key component in aging, has been a focus of limited yet inconsistent studies.
  • This study focused on the effect of 10 Hz pulsed magnetic fields on the cellular senescence of human fetal lung fibroblasts from a 2BS cell line.
  • Exposure to pulsed magnetic fields involved an intermittent schedule (1 day on/1 day off) at 1.0 mT for two weeks.
  • The results indicated DNA damage but did not show other significant phenotypes of cellular senescence in the treated cells.

Conclusion

Although the study found indications of DNA damage, no direct induction of cellular senescence was noted. This suggests a potential health risk from electromagnetic fields affecting cellular structures at a DNA level, necessitating further comprehensive studies to fully understand EMFs' implications on aging and health.

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